Povidone iodine,reddish brown free flowing amorphous power. Also called betadine and PVPI for short by many povidone manufacturers. It is complexed by polyvinylpyrrolidone PVP and I2. Since it has strong killing effect to bacteria, viruses, fungi, mold and spores with the characteristic of stable, no irritation, completely water soluble, povidone iodine’s application in pharmaceutical has gained much more attention.
PVP iodine has loaded in Chinese Pharmacopoeia, the United States Pharmacopoeia, the British Pharmacopoeia, the Japanese Pharmacopoeia, and Martin Pharmacopoeia, it was approved to use in the medical and health as the body directly use the disinfectant. China Pharmacopoeia containing povidone iodine suppository, solution, ointment and other formulations. Povidone iodine has become internationally recognized as efficient, broad-spectrum, non-toxic fungicide, it has a strong bactericidal and extensive bactericidal spectrum.
The Principle of PVPI’s antibacterial action:
PVPI polymer is a hydrophilic polymer without antibacterial effect itself. But because of its affinity for the cell membrane, iodine can lead directly to the bacterial cell surface, which is to improve the antimicrobial activity of iodine is very meaningful. The attack target of iodine is a bacterial cytoplasm and a cytoplasmic membrane that kill bacteria immediately within a few seconds. When the necessary components such as sparse compounds, peptides, proteins, lipids and cytosine are in contact with PVP-I, they are oxidized or iodized immediately by iodine to lose their activity and achieve prolonged bactericidal activity. PVP-I on bacteria, fungi, viruses and protozoa have a killing effect on the clinical common bacteria for in vitro experiments, it can killed almost bacteria.
Antibacterial spectrum of Povidone Iodine:
Povidone iodine disinfecting has excellent effect. can kill a variety of Gram-positive and negative bacteria, spores, fungi, Escherichia coli, Shigella, tetracycline, Bacillus subtilis, Proteus, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Bacteria, Citrobacter, diphtheria bacillus, Bacillus sp., Bacillus anthracis, Candida albicans, flagellates, Chlamydia.
Application of Povidone Iodine in antibacterial agent:
PVPI powder and PVPI solution has widely applicated in antibacteria. It mainly used for gynecological inflammation, psoriasis skin inflammation, oral inflammation, mouth ulcers, burns, burns, all kinds of trauma, surgery, skin disinfection before injection and disinfection of medical equipment and so on.
The application of PVPI in pharmaceutical means that the quality of PVPI must have a high standard. Huafu Chemical, the only corporation which can make PVP items of pharmaceutical grade with one-step process technology. We take orders of quality first, strive to supply high standard PVP series products including PVP K15/K25/K30/K60/K90, PVP-I, PVPP and NVP.
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